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The activation of hypothalamic neurons, suppression of food intake, and weight loss induced by liraglutide were attenuated in mice with impaired transcellular transport in tanycytes or in mice with a tanycyte-specific GLP-1 receptor knockdown [7]
Massobrio R, Bianco L, Campigotto B, Attianese D, Maisto E, Pascotto M, et al
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For this level of weight loss, expect appetite suppression to build gradually over the first 8-12 weeks, then sustain at a high level throughout the treatment period
